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Clinical data
Routes of
ATC code
Legal status
Legal status
  • UK: POM (Prescription only)
Pharmacokinetic data
Elimination half-life8 to 11 hours
CAS Number
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
Molar mass353.326 g/mol

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List of terms related to Acenocoumarol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin). It is a derivative of coumarin and is marketed under the brand names Sintrom and Sinthrome.


Research in the RECAVA network has discovered that two acquired factors (age and body mass index) and three genetic polymorphisms (genes VKORC1, CYP2C9 and CYP4F2) are useful to establish the correct dosage. Acenocoumarol is contraindicated during pregnancy.

External links

  • Template:DiseasesDB
  • Cesar J, García-Avello A, Navarro J, Herraez M (2004). "Aging and oral anticoagulant therapy using acenocoumarol". Blood Coagul Fibrinolysis. 15 (8): 673&ndash, 6. doi:10.1097/00001721-200412000-00007. PMID 15613922.
  • Lengyel M; SPORTIF-III Altanulmány Vizsgálói (2004). "Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation?". Orv Hetil. 145 (52): 2619&ndash, 21. PMID 15724697.
  • Ufer M (2005). "Comparative pharmacokinetics of vitamin Kd antagonists: warfarin, phenprocoumon and acenocoumarol". Clin Pharmacokinet. 44 (12): 1227&ndash, 46. doi:10.2165/00003088-200544120-00003. PMID 16372822.
  • Montes R, Ruiz de Gaona E, Martínez-González M, Alberca I, Hermida J (2006). "The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients". Br J Haematol. 133 (2): 183&ndash, 7. doi:10.1111/j.1365-2141.2006.06007.x. PMID 16611310.