Gs alpha subunit

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GNAS complex locus
Alt. symbolsGNAS1
Other data
LocusChr. 20 q13.2-13.3

The Gs alpha subunit (Gαs, G, or Gs protein) is a heterotrimeric G protein subunit that activates the cAMP-dependent pathway by activating adenylyl cyclase. It is one of the three main families of G proteins: Gαi/Gαo, Gαq, and Gαs.[1] A mnemonic for remembering this subunit is to look at the first letter (Gαs = Adenylate Cyclase stimulator).


The G protein-coupled receptors that couple to this kind of G-protein include:


The general function of Gs is to activate adenylyl cyclase, which, in turn, produces cAMP, which, in turn activates cAMP-dependent protein kinase. Further effects of Gs are thus found in function of cAMP-dependent protein kinase.

It provides a step in signal transduction. Amplification of the signal occurs for instance because the receptor activates several Gs.[2] However, each Gs activates only one adenylate cyclase.[2]

See also


  1. Ellis C, Nature Reviews Drug Discovery GPCR Questionnaire Participants (July 2004). "The state of GPCR research in 2004". Nature Reviews. Drug Discovery. 3 (7): 575, 577–626. doi:10.1038/nrd1458. PMID 15272499.
  2. 2.0 2.1 Purves D, Augustine GJ, Fitzpatrick D, Hall WC, LaMantia AS, White LE, eds. (2007). Neuroscience (4th ed.). New York: W. H. Freeman. p. 155. ISBN 978-0-87893-697-7.

External links